Organic Salts of Pharmaceutical Impurity p-Aminophenol
نویسندگان
چکیده
منابع مشابه
Application of Mixed Micelle-Mediated Extraction for Selective Separation and Spectrophotometric Determination of P-Aminophenol Impurity in Pharmaceutical Formulations
A procedure for separation/preconcentration of para-aminophenol (PAP) in pharmaceutical formulation, based on cloud point extraction (CPE) as a prior step to determination by UV-Vis spectrophotometry has been developed. The analyte reacted with 4-dimethylamino benzaldehyde (DAB) in acidic media to form a shift base, which were separated and preconcentrated in a mixed micelle of the anionic surf...
متن کاملPharmaceutical salts.
Keyphrases D Pharmaceutical salts-general pharmacy, physicochemical properties, bioavailability, pharmaceutical properties, toxicology, review J:J Salts, pharmaceutical-general pharmacy, physicochemical properties, bioavailability, pharmaceutical properties, toxicology, review J:J Physicochemical properties-dissolution, solubility, stability, and organoleptic properties of pharmaceutical salts,...
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There is now ample evidence that the oral administration of aspirin leads to an increase in faecal blood loss in the majority of normal people. Some investigators (Lange, 1957; Alvarez and Summerskill 1958; Stubbe, Pietersen, and Van Heulen, 1962) have used chemical means of testing for occult blood in faeces, and others (Matsumoto and Grossman, 1959; Watson and Pierson, 1960; Holt, 1960; Scott...
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Two methods for the determination of N-acetyl-p-aminophenol (APAP) in plasma that differ in principle from the diazotization procedure of Brodie and Axelrod (1) are described. One method based on the differential absorption peak of APAP at 266 m, which corresponds to the isosbestic point of common drugs such as acetylsalicylic and salicylic acids, is simple and most specific for APAP. The other...
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In view of the fact that aniline is absorbed not only by inhalation but also through the skin, the aerial contamination alone is not an exact indication of exposure. It is necessary to find a biological test which reveals exposure and is independent of the route of absorption. It is conceivable that the p-aminophenol excretion in the urine, which is a well-known symptom of aniline intoxication,...
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ژورنال
عنوان ژورنال: Molecules
سال: 2020
ISSN: 1420-3049
DOI: 10.3390/molecules25081910